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Table 1 Leukapheresis yield in advanced sarcoma patients

From: Tetramer guided, cell sorter assisted production of clinical grade autologous NY-ESO-1 specific CD8+ T cells

  Sarcoma subtype Age Chemotherapy prior to leukapharesis Sites of disease Leukapharesis yield (×10^9) Yield of CD25 depletion (×10^9)
Patient 1 SS 47 None Soft tissue, lung, brain 7.11 0.99
Patient 2 MRCL 35 Rtx Bone, soft tissue, lung 6.9 1.44
Patient 3 SS 48 A/I, HD Ifos, Rtx Brain, lung 5.14 1.2
Patient 4 SS 46 A/I/Vincristine, Rtx/Ifos Lung 14 1.365
Patient 5 SS 26 None Lung, kidney, soft tissue 11.2 1.56
Patient 6 SS 42 None Recurrent, locally advanced axillary disease 13.76 1.46
  1. Rtx - Radiation therapy; A/I - Adriamycin and Ifosfamide; Gem/tax - gemcitabine and docetaxel; Doxil - liposomal doxorubicin; A/I/DTIC - Adriamycin, Ifosfamide and Decarbazine.