Rejection of the MC57-SIY tumor is dependent on CARMA1 but not MyD88 expression. One million MC57-SIY tumor cells were subcutaneously injected into either MyD88-KO (a) or CARMA1-KO (b) mice, and tumor growth was measured over time. c) Wildtype and CARMA1-KO mice were subcutaneously injected with 106 MC57-SIY tumor cells and sacrificed 7 days later. Enriched splenic CD8+ T cells were restimulated with γ-irradiated MC57-SIY cells and an ELISpot was used to measure the frequency of cells secreting IFN-γ. The experiment was repeated 3 times with 3–5 mice per group/experiment. **p < 0.01, ***p < 0.001.