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Figure 8 | Journal for ImmunoTherapy of Cancer

Figure 8

From: Early transduction produces highly functional chimeric antigen receptor-modified virus-specific T-cells with central memory markers: a Production Assistant for Cell Therapy (PACT) translational application

Figure 8

Improved proliferation of early transduced triVSTs. Early transduced (ET) and late transduced (LT) triVST with retrovirus expressing GD2.CAR were co-cultured for 72 hours with (A) GD2-positive LAN-1 neuroblastoma cells, or with (B) autologous LCLs at 4:1 of VST to LCL ratio or (C) Ad5f35-pp65-transduced LCLs (LCL-Adpp65). Proliferation of CD3+ T cells was evaluated by eFluor dilution by flow cytometry. Histograms are representative results from one donor. Cell division indexes were calculated using FlowJo software. Results are shown as mean ± SD, n = 3.

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