Measurement of AGS-003 induced multifunctional CD8
CTLs and correlation with overall survival. Absolute number of CD28+/CD45RA- CTLs in response to DCs electroporated with autologous amplified RCC tumor RNA at baseline (A) and after 5 doses of AGS-003 (B). Increase in the number of CD28+/CD45RA- CTL from baseline to post 5th dose (C). Patients are listed by in increasing order of overall survival (D). Blue bars () identify intermediate risk patients and red bars () identify poor risk patients. The correlation between the absolute number of CD28+/CD45RA- CTLs and overall survival was statistically significant by nonparametric bivariate analysis, Spearman’s ρ = 0.8; p < 0.002.