Role of CD4+ and CD8+ lymphocyte subsets in controlling tumor growth. NSG mice were reconstituted with either 1x107 human PBL (huPBL-NSG) or PBL from the same donor that had been depleted of CD8+ T cells [huPBL-NSG (−CD8); A] or depleted of CD4+ T cells [huPBL-NSG (−CD4); B]. On the same day they received 2x106 PC3 cells implanted by s.c. injection. Tumors were recovered after 3 weeks and individually weighed. Values represent mean of three animals per group ± SD. *p < 0.05. Representative experiment, n = 3 experiments.