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Figure 5 | Journal for ImmunoTherapy of Cancer

Figure 5

From: Human tumor infiltrating lymphocytes cooperatively regulate prostate tumor growth in a humanized mouse model

Figure 5

Role of CD4+ and CD8+ lymphocyte subsets in controlling tumor growth. NSG mice were reconstituted with either 1x107 human PBL (huPBL-NSG) or PBL from the same donor that had been depleted of CD8+ T cells [huPBL-NSG (−CD8); A] or depleted of CD4+ T cells [huPBL-NSG (−CD4); B]. On the same day they received 2x106 PC3 cells implanted by s.c. injection. Tumors were recovered after 3 weeks and individually weighed. Values represent mean of three animals per group ± SD. *p < 0.05. Representative experiment, n = 3 experiments.

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