Figure 5From: Human tumor infiltrating lymphocytes cooperatively regulate prostate tumor growth in a humanized mouse model Role of CD4+ and CD8+ lymphocyte subsets in controlling tumor growth. NSG mice were reconstituted with either 1x107 human PBL (huPBL-NSG) or PBL from the same donor that had been depleted of CD8+ T cells [huPBL-NSG (āCD8); A] or depleted of CD4+ T cells [huPBL-NSG (āCD4); B]. On the same day they received 2x106 PC3 cells implanted by s.c. injection. Tumors were recovered after 3Ā weeks and individually weighed. Values represent mean of three animals per groupāĀ±āSD. *pā<ā0.05. Representative experiment, nā=ā3 experiments.Back to article page