Figure 4

FOXP3+ T cells were more likely to be detected in the intraepithelial compartment and CD4 T cells in the stroma compared to CD3 T cells, which were found equally in stroma and intraepithelial compartments (A) CD3 immunohistochemistry (i) compared to Rat IgG isotype control (ii). (B) FOXP3 T-cell immunohistochemistry (i) compared to Rat IgG isotype control (ii). (C) Box and whisker plot showing percent CD3 (n = 10), CD4 (n = 10), and FOXP3 (n = 10) cells from immunohistochemistry compared between stromal and intraepithelial sections. (D) Representative images of stromal and intraepithelial lymphocyte infiltration in the stromal (i) and intraepithelial (ii) compartments by H and E (a), CD3 (b), CD4 (c), and FoxP3 (d).