Figure 6
NK and CD8+ T cells are necessary for combination IL-2 and CTLA-4 blockade immunotherapy-mediated effects. (A) Schematic of the experimental design. (B) Cumulative graph of the mean tumor size (mm2) per group after CD8 or NK cell depletion (left panel) and B cell or CD4+ cell depletion (right panel) from the experiment described in (A). (C) Cumulative graph of the mean tumor size (mm2) per group after combination CD8 and NK cell depletion from the experiment described in (A). (D) Tumor size (mm2) of individual mice in each group from experiment described in (C). Four to ten mice were included in each group. Graphs represent one experiment of three conducted with similar results. *P < 0.05, **P < 0.001, ***P < 0.001, ns = not significant.