Figure 4

Myeloma tumors express survivin mRNA and protein which negatively correlate with survivin reactive CD4+ T cell frequency. A. mRNA expression negatively correlates to the de-novo survivin reactive CD4+CD25- T cell precursor frequency as calculated by LDA. (p = 0.0028 and r = −1.0 by Spearman nonparametric correlation analysis). B. Survivin protein expression, evaluated by the Allred score [46], negatively correlates to the de-novo survivin reactive CD4+CD25- T cell precursor frequency as calculated by LDA. (p = 0.0028 and r = −1.0 by Spearman nonparametric correlation analysis).