Fig. 3

Cy administered prior to lysate/CpG treatment eliminates existing neuroblastoma. Groups of mice received ip Cy in doses of 50, 75 or 100 mg/kg followed by either no treatment or 4 weekly treatments of lysate/CpG according to the schedule in Fig. 2a. In addition to lysate/CpG, some mice received 200 μg of anti-Thy1.2 antibody ip on days 14, 18, 22 and 26. Mice were followed for survival and euthanized when tumor size reached 250 mm². Each graph represents data combined from 2 separate experiments with 5 mice per group. Data was analyzed for statistical significance using the log-rank (Mantel-Cox) test