Fig. 6From: Characterization of the human T cell response to in vitro CD27 costimulation with varlilumabConventional T cells, but not CD4+CD25hiFoxP3+ (Tregs), can be stimulated by varlilumab to produce cytokines and proliferate. Magnetically isolated Tregs (CD4+/CD25hi/FoxP3+) were compared with CD3+ T cells from the same donor a for their response to stimulation with OKT3/varlilumab, OKT3/CD28 or OKT3/control IgG; and b CFSE-labeled OKT3-activated and varlilumab stimulated pan T cells were first gated on CD4+CD25+ subset, this subset was then plotted by CFSE and FoxP3. Rectangular gates were drawn to indicate FoxP3- (lower rectangular), FoxP3+ non-dividing (upper-right rectangular), and FoxP3+ dividing (upper-left rectangular), subsetsBack to article page