Table 4 IL-2 pathway genes modulated by Varlilumab stimulation of T cells
From: Characterization of the human T cell response to in vitro CD27 costimulation with varlilumab
Gene Symbol | Description |
|---|---|
Induced pathway genes | |
 CD40LG | CD40 Ligand |
 IL1RAP | Interleukin 1 receptor accessory protein |
 IL13 | Interleukin 13 |
 ADD2 | Adducin 2 (beta) |
 CTNNA1 | Catenin (cadherin-associated protein) alpha 1 |
 TERT | Telomerase reverse transcriptase |
 LAIR2 | Leukocyte-associated Ig-like receptor 2 |
 MYC | v-myc Myelocytomatosis viral oncogene homolog (avian) |
 LIF | Leukemia inhibitory factor |
 DUSP6 | Dual specificity phosphatase 6 |
 OSM | Oncostatin M |
 CSF2 | Colony stimulating factor 2 (granulocyte-macrophage) |
 IER3 | Immediate early response 3 |
 CSF1 | Colony stimulating factor 1 (macrophage) |
 NTRK1 | Neurotrophic tyrosine kinase receptor type 1 |
 NFIL3 | Nuclear factor, interleukin 3 regulated |
 IL5 | Interleukin 5 |
 GZMB | Granzyme B (granzyme 2, CTL-associated serine esterase 1 |
 XCL1 | Chemokine (C motif) ligand 1 |
 IL6 | Interleukin 6 (interferon beta 2) |
 IL10 | Interleukin 10 |
 CD300A | CD300a molecule |
 IL9 | Interleukin 9 |
 PRSS23 | Protease serine 23 |
 PHLDB2 | Pleckstrin homology-like domain, family B, member 2 |
Repressed pathway genes | |
 CXCR5 | Chemokine (C-X-C motif) receptor 5 |
 MYC | v-myc Myelocytomatosis viral oncogene homolog (avian) |
 APP | Amyloid beta (A4) precursor protein |
 IL24 | Interleukin 24 |