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Table 4 IL-2 pathway genes modulated by Varlilumab stimulation of T cells

From: Characterization of the human T cell response to in vitro CD27 costimulation with varlilumab

Gene Symbol Description
Induced pathway genes
 CD40LG CD40 Ligand
 IL1RAP Interleukin 1 receptor accessory protein
 IL13 Interleukin 13
 ADD2 Adducin 2 (beta)
 CTNNA1 Catenin (cadherin-associated protein) alpha 1
 TERT Telomerase reverse transcriptase
 LAIR2 Leukocyte-associated Ig-like receptor 2
 MYC v-myc Myelocytomatosis viral oncogene homolog (avian)
 LIF Leukemia inhibitory factor
 DUSP6 Dual specificity phosphatase 6
 OSM Oncostatin M
 CSF2 Colony stimulating factor 2 (granulocyte-macrophage)
 IER3 Immediate early response 3
 CSF1 Colony stimulating factor 1 (macrophage)
 NTRK1 Neurotrophic tyrosine kinase receptor type 1
 NFIL3 Nuclear factor, interleukin 3 regulated
 IL5 Interleukin 5
 GZMB Granzyme B (granzyme 2, CTL-associated serine esterase 1
 XCL1 Chemokine (C motif) ligand 1
 IL6 Interleukin 6 (interferon beta 2)
 IL10 Interleukin 10
 CD300A CD300a molecule
 IL9 Interleukin 9
 PRSS23 Protease serine 23
 PHLDB2 Pleckstrin homology-like domain, family B, member 2
Repressed pathway genes
 CXCR5 Chemokine (C-X-C motif) receptor 5
 MYC v-myc Myelocytomatosis viral oncogene homolog (avian)
 APP Amyloid beta (A4) precursor protein
 IL24 Interleukin 24