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Fig. 1 | Journal for ImmunoTherapy of Cancer

Fig. 1

From: Increased CTLA-4+ T cells and an increased ratio of monocytes with loss of class II (CD14+ HLA-DRlo/neg) found in aggressive pediatric sarcoma patients

Fig. 1

Alterations in peripheral blood immune phenotypes in pediatric sarcoma patients. Immune phenotypes from healthy volunteers and pediatric sarcoma patients were measured by flow cytometry. a. The percentages of granulocytes, lymphocytes, and monocytes of total leukocytes as measured by forward and side scatter properties in healthy volunteers and sarcoma patients. Comparison of cell counts (Cells/μl) of: b, T cells (Left axis), B cells (Right axis), and NK cells (Right axis); c, CD4, CD8 and the CD4:CD8 ratio (CD4 cell counts/CD8 cell counts); d, CD4 cell counts in osteogenic sarcoma versus Ewing’s sarcoma; e, CTLA-4+ CD4 and CD8 cells. Increases in the percentages of f, CD19+CD27+IgD−IgM− B cells and g, CD14+HLA-DRlo/neg monocytes; h, and an increase of expression of TNFRII (by mean flourescenc intensity) on monocytes was observed in sarcoma patients. P values are listed where values are < 0.05

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