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Table 1 Patient characteristics

From: Increased CTLA-4+ T cells and an increased ratio of monocytes with loss of class II (CD14+ HLA-DRlo/neg) found in aggressive pediatric sarcoma patients

Patient number Diagnosis Age (years) Gender Primary site Metastases Enrollment Prior therapy From last therapy Blood analysis Tissue analysis (months since)
1 OS 16 Male Distal femur B/L Pulmonary ND None NA Yes Yes Local Relapse 30 months, alive, NED
2 OS 18 Male Pelvis None ND None NA Yes No DOD
3 OS 12 Female Proximal humerus None ND None NA Yes Yes NED 24 mths
4 OS 10 Female Proximal humerus U/L pulmonary ND None NA Yes Yes Local Relapse 27 months, alive, NED
5 OS 21 Male Distal femur None ND None NA Yes No NED 27 mths
6 OS 13 Female Proximal tibia None ND None NA Yes Yes Died of pulmonary embolism during surgery
7 OS 16 Female Distal femur None ND None NA Yes Yes NED 20 mths
8 OS 14 Female Proximal tibia None ND None NA Yes Yes NED 20 mths
9 OS 7 Male Distal femur None ND None NA Yes Yes NED 19 mths
10 OS 15 Male Craniofacial None ND None NA Yes No NED 19 mths
11 OS 12 Female Distal femur B/L Pulmonary ND None NA Yes Yes DOD 22 mths
12 ES 14 Female Scapula None Relapse VDC/ IE 12 weeks Yes Yes DOD 36 mths
13 ES 19 Male Pelvis B/L Pulmonary Relapse VDC/ IE 8 weeks Yes Yes DOD 28 mths
14 ES 18 Male Spine None ND None NA Yes No Died in a car accident 6 mths after diagnosis
15 ES 13 Male Pelvis None ND None NA Yes Yes NED 29 mths
16 ES 22 Male Chest wall None Relapse VDC/ IE 4 years Yes No NED 72 mths
      Diffuse bone and       DOD 13
17 ES 6 Female Scapula bone marrow ND None NA No Yes mths
18 ES 13 Female Sacrum None ND None NA Yes Yes NED 20 mths
19 ES 7 Male Mandible proximal None ND None NA Yes No NED 17 mths
20 ES 13 Male Humerus None ND None NA Yes Yes NED 15 mths
  1. DOD- died of disease
  2. NED- no evidence of disease
  3. ND- new diagnosis
  4. VDC/IE- Vincristine, doxorubicin, cyclophosphamide, ifosfamide and etoposide