Increased CTLA-4+ T cells and an increased ratio of monocytes with loss of class II (CD14+ HLA-DRlo/neg) found in aggressive pediatric sarcoma patients

Table 1 Patient characteristics

Patient number	Diagnosis	Age (years)	Gender	Primary site	Metastases	Enrollment	Prior therapy	From last therapy	Blood analysis	Tissue analysis	(months since)
1	OS	16	Male	Distal femur	B/L Pulmonary	ND	None	NA	Yes	Yes	Local Relapse 30 months, alive, NED
2	OS	18	Male	Pelvis	None	ND	None	NA	Yes	No	DOD
3	OS	12	Female	Proximal humerus	None	ND	None	NA	Yes	Yes	NED 24 mths
4	OS	10	Female	Proximal humerus	U/L pulmonary	ND	None	NA	Yes	Yes	Local Relapse 27 months, alive, NED
5	OS	21	Male	Distal femur	None	ND	None	NA	Yes	No	NED 27 mths
6	OS	13	Female	Proximal tibia	None	ND	None	NA	Yes	Yes	Died of pulmonary embolism during surgery
7	OS	16	Female	Distal femur	None	ND	None	NA	Yes	Yes	NED 20 mths
8	OS	14	Female	Proximal tibia	None	ND	None	NA	Yes	Yes	NED 20 mths
9	OS	7	Male	Distal femur	None	ND	None	NA	Yes	Yes	NED 19 mths
10	OS	15	Male	Craniofacial	None	ND	None	NA	Yes	No	NED 19 mths
11	OS	12	Female	Distal femur	B/L Pulmonary	ND	None	NA	Yes	Yes	DOD 22 mths
12	ES	14	Female	Scapula	None	Relapse	VDC/ IE	12 weeks	Yes	Yes	DOD 36 mths
13	ES	19	Male	Pelvis	B/L Pulmonary	Relapse	VDC/ IE	8 weeks	Yes	Yes	DOD 28 mths
14	ES	18	Male	Spine	None	ND	None	NA	Yes	No	Died in a car accident 6 mths after diagnosis
15	ES	13	Male	Pelvis	None	ND	None	NA	Yes	Yes	NED 29 mths
16	ES	22	Male	Chest wall	None	Relapse	VDC/ IE	4 years	Yes	No	NED 72 mths
					Diffuse bone and						DOD 13
17	ES	6	Female	Scapula	bone marrow	ND	None	NA	No	Yes	mths
18	ES	13	Female	Sacrum	None	ND	None	NA	Yes	Yes	NED 20 mths
19	ES	7	Male	Mandible proximal	None	ND	None	NA	Yes	No	NED 17 mths
20	ES	13	Male	Humerus	None	ND	None	NA	Yes	Yes	NED 15 mths