Fig. 2

Change in index lesion response. Waterfall plots demonstrating index lesion responses for instances where sequential radiologic measurements were available. Both the percent change in the longest diameter of the index lesion after cranial irradiation (top, n = 29) and “delta-delta”, difference in percent change from the two imaging studies performed before cranial irradiation and before and after radiation (bottom, n = 22) are shown. Instances where ipilimumab was not given within three months of radiation are shown in blue, administration of both ipilimumab and radiation within a three-month span are shown in red