Fig. 3

Tasquinimod induces tumor immunomodulation and inhibits tumor angiogenesis within one week of exposure. a CD31 staining of tumors from control and tasquinimod treated animals. Mice were treated for 1, 5 or 7 days with tasquinimod (p.o.; 30 mg/kg/day). b Hypoxia-induced expression of Hif-1α controlled genes in tumor samples; SemaphorinB (left panel) and Glut-1 (right panel) after 7 days of exposure. c Time study of mRNA expression in tumors treated with tasquinimod for 1 up to 7 days of exposure CD206 (Mrc1) (left panel) and Nos2 (right panel) (versus control; * p < 0.05; ** p < 0.01 and *** p < 0.001; One way ANOVA with Dunnetts multiple comparison test, Error bars indicate s.e.m)