Fig. 5

Tasquinimod-induced functional changes in tumor derived CD11b⁺. a Changes of Arg-1 and Il-12β mRNA levels in isolated tumor infiltrating CD11b⁺ cells stimulated with LPS/IFNγ and cultured ex vivo for 24 h. Results from one out of three representative experiments are shown (* p < 0.05; t-test, Error bars indicate s.e.m). b IL-12(p40) cytokine production of tumor lysates prepared from treated and non-treated tumors (*p < 0.05 Jonckheere-Terpstra test; Error bars indicate s.e.m)