Table 4 Important human NK cell receptors in cancer immunotherapy
Receptor family | Cluster of Designation | Ligand |
|---|---|---|
Activating receptors | Â | Â |
FcγRIIIa (CD16) | CD16 | Immunoglobulin G |
DNAM-1 | CD226 | Nectin-2 (CD112), PVR (CD155) |
NKG2D | CD314 | MICA, MICB, ULBPs |
NKp46 | CD335 | Viral HA, HN |
NKp30 | CD337 | B7-H6 |
2B4 | CD244 | CD48 |
CS1 | CD319 | CS1 |
NKG2C | CD158c | HLA-E |
KIR2DS1/2/3 | CD158h,j | HLA-C2 |
NKp80 | n/a | AICL |
Inhibitory receptors | Â | Â |
KIR2DLs | CD158a,b | HLA-C1,C2 |
KIR3DLs | CD158,e,f,k | HLA-A,B |
NKG2A | CD159a | HLA-E |
LIR-1 | CD85j | HLA-A,B,C |
| Â | Â | (allele-specific HLA-B and HLA-C) |
Adhesion/Trafficking receptors | Â | Â |
N-CAM | CD56 | CD56, FGFR1 |
L-selectin | CD62L | GlyCAM-1, CD34, PSGL-1 |
PEN-5/PSGL-1 | CD162 | Selectins |
LFA-1 | CD11a | ICAMs |
LFA-2 | CD2 | CD58 |
LFA-3 | CD58 | CD2 |
αMβ2 | CD11b | fibrinogen, C3bi, ICAM-4 |