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Table 5 Important human cytokine and chemokine receptors in cancer immunotherapy

From: Immunodynamics: a cancer immunotherapy trials network review of immune monitoring in immuno-oncology clinical trials

Receptor family Cluster of Designation Ligands
Cytokine/Chemokine receptors   
IL-1R CD121a IL-1β
IL-2Rα CD25 IL-2 (high affinity)
IL-2/15Rβγ CD122/CD132 IL-2/15 (intermediate affinity)
IL-7Rα CD127 IL-7
c-KIT CD117 stem cell factor
CCR2 CD192 MCP-1 (CCL2)
CCR5 CD195 MIP-1α, RANTES, MCP-3, MIP5
CCR7 CD197 CCL19,CCL21
CXCR1 CD128 IL-8
CXCR3 CD183 CXCL9-11
CXCR4 CD184 CXCL2
CX3CR1 n/a Fractalkine