Skip to main content

Table 1 Cellular Microenvironment of Pancreatic Cancer

From: From bench to bedside a comprehensive review of pancreatic cancer immunotherapy

Cell Role in pancreatic cancer Relationship to outcome Reference
NK deactivated ↑tumor stage and ↓survival [1113]
CD8+ T-Cell deactivated ↑tumor stage and ↓survival [5, 8, 13]
CD4+ Th1-Cell ↑tumor stage and ↓survival [1214]
TAM (M1) ↑tumor stage [4, 1214]
DC deactivated ↑survival [8, 13, 17, 18]
MDSC ↓survival [5, 12, 16, 24]
Mast Cell ↑metastases [9, 13]
T-regs ↓survival [4, 5, 12, 22, 23]
TAM (M2) ↑stage and ↓survival [4, 1214]
Fibroblast ↑stage and ↓survival [12, 13, 25, 27]
CD4 + Th2 Cell ↑stage and ↓ survival [5, 9, 1214, 16, 25]
  1. ↑ increase, ↓ decrease, DC dendritic cell, MDSC myeloid derived suppressor cell, NK natural killer cell, TAM tumor associated macrophage