Skip to main content

Table 3 Expression of genes related to a TH1 type gene signature before and after treatment in selected patients

From: Phase I study with ONCOS-102 for the treatment of solid tumors – an evaluation of clinical response and exploratory analyses of immune markers

 

FI1-09

FI1-14

FI1-19

Gene

baseline

after

baseline

aftera

baseline

after

Granzyme B

7.3

8.5

7.2

10.1

na

9.9

Granulysin

8.3

7.2

7.1

9.0

na

8.9

Perforin

7.3

8.1

7.1

9.6

na

9.7

IFNγ

6.8

7.7

6.9

8.6

na

7.6

IRF1

9.3

10.7

10.6

11.9

na

11.9

RANTES

8.4

11.6

9.3

12.9

na

12.3

CXCL9

7.5

10.8

9.3

12.4

na

10.5

CXCL10

8.7

10.5

10.2

11.8

na

10.3

  1. Baseline = before treatment, after = 2 months after the treatment initiation
  2. a= 1 month after the treatment initiation
  3. IFNγ interferon gamma, IRF1 interferon regulatory factor 1