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Table 1 Stimulants currently available for the TruCulture® Whole Blood Collection and Culture system

From: Immune monitoring technology primer: immunoprofiling of antigen-stimulated blood

Description of stimulant Target
Null TruCulture (TC) tube (TC Tubes Null) Control
Tumor Necrosis factor (TNF)-alpha tube (TC Tubes TNF-α 10 ng/ml) Cytokine
Intron A/Interferon (IFN)-alpha tube (TC Tubes IFN-α) Cytokine
Interferon (IFN)-beta tube (TC Tubes IFN-β) Cytokine
Interleukin (IL)-1beta + TNF-α tube (TC Tubes IL-1β + TNF-α) Cytokine
Intron A/IFN-α + anti-CD3 + anti-CD28 tube (TC Tubes IFN-α + CD3 + CD28) Cytokine
Intron A/IFN-α + Lipopolysaccharide (LPS)-EB (Escherichia coli 0111:B4) high concentration tube (TC Tubes IFN-α + LPS-EB) Cytokine/TLR4 Ligand
Adenosine Triphosphate (ATP) + LPS-EB tube (TC Tubes ATP + LPS-EB) NLRP3 Inflammasome/TLR4 Ligand
Lauroyl-γ-D-glutamyl-meso-diaminopimelic acid (C12-iE-DAP) tube (TC Tubes C12-iE-DAP) NOD Ligand
Lipoarabinomannan (LAM) from M. smegmatis tube (TC Tubes LAM-MS) NOD Ligand
Staphylococcal Enterotoxin B (SEB) tube (TC Tubes SEB) T-Cell
Anti-CD3/CD28 tube (TC Tubes CD3 + CD28) T-Cell
SEB/anti-CD28 tube (TC Tubes SEB + CD28) T-Cell
anti- CD3 tube (TC Tubes CD3) T-Cell
Zymosan (ZYM) tube (TC Tubes ZYM) TLR2 Ligand
Fibroblast-stimulating Lipopeptide (FSL) tube (TC Tubes FSL-1) TLR2 Ligand
Heat killed E. coli 0111:B4 tube (TC Tubes HKEB) TLR2 Ligand
Heat Killed Lactobacillus rhamnosus tube (TC Tubes HKLR) TLR2 Ligand
Polyinosinic:polycytidylic acid (Poly I:C) tube (TC Tubes Poly I:C) TLR3 Ligand
LPS tube (TC Tubes LPS) TLR4 Ligand
LPS-EB high concentration tube (TC Tubes LPS-EB) TLR4 Ligand
LPS + SEB tube (TC Tubes LPS + SEB) TLR4 Ligand/T-Cell
Resiquimod R848 tube (TC Tubes R848) TLR7/8 Ligand
Gardiquimod (GDQ) tube (TC Tubes GDQ) TLR7/8 Ligand
Class A CpG oligonucleotide + LPS-EB high concentration tube (TC Tubes ODN2216 + LPS-EB) TLR9 Ligand