Fig. 2

HER2 specific T-cells trafficked to and infiltrated all sites of metastatic disease over a 48 h period. a Whole body planar images of In-111 labeled T-cells (i) anterior and (ii) posterior views 24 h after infusion show focal areas of increased uptake in the left postero-lateral skull, both humeral heads, mid-sternum, and R sacrum (arrows). b SPECT/CT fused image of In-111 T-cells acquired 24 h post infusion; humeral heads show T-cell infiltrates (pink). c In-111 uptake in counts/pixel normalized to background at 4 h (white), 24 h (grey), and 48 h (black) after infusion