Fig. 2

Treatment of CSCs in vivo with drozitumab (α-DR5) prevents tumor development. a) Experimental design schematic. Purified triple positive cancer stem cells from b) 11424, c) 14244, and d) 12424 were engrafted in SCID mice and mice were immediately treated with either vehicle (control) or drozitumab until the majority of control mice developed tumors. Arrows indicate duration of treatment. After treatment with drozitumab was discontinued, tumor-free mice were monitored for tumor development. n = 6–8 mice/group. Statistics by Mantel-Cox test; **p <0.01, ***p <0.001