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Fig. 3 | Journal for ImmunoTherapy of Cancer

Fig. 3

From: Pancreatic cancer stem cells in patient pancreatic xenografts are sensitive to drozitumab, an agonistic antibody against DR5

Fig. 3

CSCs express higher levels of death receptors compared with bulk tumor cells. a Gating strategy for identifying cancer stem cells. Tumors were dissociated with type IV collagenase and gated on ESA+ cells (not shown), followed by CD24+ and CD44+ populations. b) Percentage of cancer stem cells in patient xenografts 11424, 14244 and 12424. c) Representative plots of DR4, DR5, DcR1, DcR2 expression on triple positive cancer stem cells and bulk tumor cells compared with unstained controls. Background staining of isotype controls (Iso) was comparable to unstained cells (Unst). d) Analysis of percentage of cells expressing DR4, DR5, DcR1 and DcR2. Statistics by Student t-test; ****p <0.0001. Experiment performed three times in triplicate

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