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Fig. 3 | Journal for ImmunoTherapy of Cancer

Fig. 3

From: Phenotypic and functional testing of circulating regulatory T cells in advanced melanoma patients treated with neoadjuvant ipilimumab

Fig. 3

Association between reduced progression free survival with increase in circulating Treg. The patients were divided into two groups: those with % inhibition increased and those with % inhibition decreased. We defined the group by taking a majority of the three ratios. That is, if the results of at least 2 of the 3 ratios indicated a higher % inhibition at week 6 than at baseline, the patient was included in the WK6 > BL group, and if the results of at least 2 of the 3 ratios indicated a lower % inhibition at week 6 than at baseline, then the patient was included in the WK6 < BL group. Suppressive activity over time is shown in a Kaplan-Meier plot. Increase in Treg suppressive function was significantly associated with a decrease in PFS (p = 0.02381)

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