Fig. 2
From: Grover’s-like drug eruption in a patient with metastatic melanoma under ipilimumab therapy
Skin findings after the second course of ipilimumab treatment. a) Clinical presentation. Overview image showing the diffuse eruption of a papulovesicular rash on the patient’s trunk (left). Detail image showing lesions of different stages ranging from early erythematous papules to crusty and scaly erosions (right). b Histopathological findings on skin biopsy (Hematoxylin-eosin stain). Overview image demonstrating circumscript acantholytic dyskeratosis and mild interface dermatitis with perivascular accentuation as an accompanying feature (left). Detail image showing Darier-like features with acatholytic and dyskeratotic keratinocytes present at all levels of the epidermis (right). Scale bars are indicated.