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Fig. 1 | Journal for ImmunoTherapy of Cancer

Fig. 1

From: Adenosine-generating ovarian cancer cells attract myeloid cells which differentiate into adenosine-generating tumor associated macrophages – a self-amplifying, CD39- and CD73-dependent mechanism for tumor immune escape

Fig. 1

Prognostic value of CD39 and CD73 expression in patients with high-grade serous OvCA. Using the ovarian cancer dataset available via the free online tool Kaplan-Meier plotter (http://kmplot.com/analysis/index.php?p=service&cancer=ovar), expression of CD39 and CD73 was correlated with overall survival. All 347 patients with stage 3 and 4 serous OvCA were included, regardless of p53 status, CA125 levels, optimal /suboptimal debulking or chemotherapy. Based on a bioinformatically computed combined classifier comprising gene expression data for both CD39/ ENTPD1 (Affymetrix ID 228585) and CD73/NT5E (Affymetrix ID 203939), 134 patients (38.6 %) were classified as CD39/CD73high. Survival probabilities according to Kaplan-Meier were calculated together with 95 % confidence intervals (CIs) and compared using two-sided log-rank tests

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