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Fig. 3 | Journal for ImmunoTherapy of Cancer

Fig. 3

From: Adenosine-generating ovarian cancer cells attract myeloid cells which differentiate into adenosine-generating tumor associated macrophages – a self-amplifying, CD39- and CD73-dependent mechanism for tumor immune escape

Fig. 3

CD39 is expressed on TAM while CD73 is strongly related to tumor stroma in OvCA. Representative immunohistochemical stainings for (a-b) CD39 and (c-d) CD73 showing that (a) CD39 is heterogeneously expressed on cells within the tumor parenchyma (b: tonsil serving as positive control) while (c) CD73 expression is largely restricted to the tumor stroma (d: placenta serving as positive control). (e-f) Immunfluorescent double stainings for (e) CD39 and IBA-1 as well as (f) CD73 and CD68 revealed a considerable co-expression of the macrophages markers with (e) CD39 but not with (f) CD73

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