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Table 3 Organ dysfunction in individual patients

From: Safety and efficacy of anti-PD-1 in patients with baseline cardiac, renal, or hepatic dysfunction

Baseline organ dysfunction Baseline measurements Worsening dysfunction (grade)
Renal and hepatic Creatinine 2.6, cirrhosis on imaging Edema (1)
 Renal Creatinine 3.0 Acute kidney injury (2)
 Renal Creatinine 2.2 Ascites (3)
 Renal Creatinine 4.6 Acute kidney injury (1)
Renal and cardiac Creatinine 2.6, Ejection fraction 40 % Acute kidney injury (1), volume overload (3)
 Cardiac Ejection fraction 30 % Decompensated heart failure (3)
 Cardiac Ejection fraction 20 % Decompensated heart failure (3)
Liver and cardiac Ejection fraction 45 %, cirrhosis on imaging Volume overload and decompensated heart failure (3)