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Fig. 1 | Journal for ImmunoTherapy of Cancer

Fig. 1

From: Anti-PD-1 increases the clonality and activity of tumor infiltrating antigen specific T cells induced by a potent immune therapy consisting of vaccine and metronomic cyclophosphamide

Fig. 1

DPX vaccination and mCPA treatment increased infiltration of C3 tumors with PD-1+ CD8α+ T cells. Mice bearing C3 tumors were treated with mCPA and vaccinated with DPX-R9F. Eight days after vaccination, mice were terminated. Tumors were dissociated and analysed by flow cytometry for expression of CD45, CD8a, PD-1 and PD-L1. a Percent CD8α positive of CD45 positive cells; b Percent PD-1 positive of CD8α&CD45 double positive cells; c Percent PD-1 positive of CD45 negative cells; d Percent PD-L1 positive of CD45 negative cells Results pooled from two separate experiments, n = 6–8, average ± SEM, statistics by students t-test, ** p < 0.01, ***p < 0.0001

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