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Fig. 3 | Journal for ImmunoTherapy of Cancer

Fig. 3

From: Anti-PD-1 increases the clonality and activity of tumor infiltrating antigen specific T cells induced by a potent immune therapy consisting of vaccine and metronomic cyclophosphamide

Fig. 3

IFN-γ ELISpot analysis of C3 tumor bearing mice treated with vaccination, metronomic cyclophosphamide, and anti-PD-1. a Responses in the spleen b Responses in the vaccine draining lymph node c responses in the tumor draining lymph node. DC-E: Unloaded (empty) dendritic cells; DC-Irr: dendritic cells loaded with irrelevant (R9L) peptide; DC-R9F: dendritic cells loaded with R9F peptide. Results representative of at least two separate experiments, n = 3–5, statistics by 2-way ANOVA with Tukey post-test, **p < 0.01

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