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Fig. 2 | Journal for ImmunoTherapy of Cancer

Fig. 2

From: Fusion of the dendritic cell-targeting chemokine MIP3α to melanoma antigen Gp100 in a therapeutic DNA vaccine significantly enhances immunogenicity and survival in a mouse melanoma model

Fig. 2

Vaccine effects on tumor growth in therapeutic model. Vaccinations occurred on days 3, 10, and 17 post challenge. a Tumor growth rate was assessed between days 10 and 16, day 10 being the point at which tumor growth of the negative control group began accelerating and day 16 being the point at which mice began to be censored due to endpoints being reached. The graph shows one representative experiment of two, five to seven mice per group and includes linear regression lines and slopes. The slope of tumor growth among recipients of MIP3α-gp100 vaccine differed significantly from dMIP3α-gp100, MIP3α-CSP, and mock PBS vaccination, as evaluated using a statistical mixed effects regression model. The groups receiving dMIP3α-gp100 and MIP3α-CSP did not differ significantly compared to each other or to the group receiving mock vaccination. Error bars represent standard error. b Tumor size at day 14 post challenge, the last point before any mice were removed from experiments. The data are representative of two experiments, with 5–8 mice per group per experiment. MIP3α-gp100 vaccine recipients had significantly smaller tumors compared to dMIP3α-gp100, MIP3α-CSP, and mock PBS vaccinated mice, as determined by ANOVA. dMIP3α-gp100 and MIP3α-CSP were not significantly different from each other or from mock. *p < 0.05, **p < 0.01, ***p < 0.001

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