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Fig. 3 | Journal for ImmunoTherapy of Cancer

Fig. 3

From: Fusion of the dendritic cell-targeting chemokine MIP3α to melanoma antigen Gp100 in a therapeutic DNA vaccine significantly enhances immunogenicity and survival in a mouse melanoma model

Fig. 3

Vaccine effects on mouse survival in a therapeutic model. Vaccinations occurred on days 3, 10, and 17 post challenge. Mice were removed from the study at the following endpoints: death, tumor size surpassing 2 cm in any dimension, or excessive tumor bleeding and ulceration. Data representative of two experiments, 5–8 mice per group per experiment. Mice in the MIP3α-gp100 vaccine group exhibit significantly enhanced survival compared to the dMIP3α-gp100, MIP3α-CSP, and mock PBS vaccination groups by the log-rank test. dMIP3α-gp100 and MIP3α-CSP did not differ significantly from each other or from mock. *p < 0.05, **p < 0.01, ***p < 0.001

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