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Table 3 Phenotype of Canine Immune Subsets

From: Canine cancer immunotherapy studies: linking mouse and human

Cell

Positive CD Markers

Negative CD Markers

Helper T cell

CD4,a CD45

CD21

Cytotoxic T cell

CD8, CD45, IFN-γ

CD21

Activated Memory T cell

CD25, CD44, CD45, CD69

CD62L

Regulatory T cell

CD4, CD25, CD45, FoxP3

CD8

B cell

CD22, CD79a, CD45, CD25, MHC2

TCR

Dendritic cell

CD11c, MHC II, CD80, CD14

N/A

Macrophage

MHC II, Mac-3/Lamp2/107b, F4/80, CD11b, CD206

N/A

Natural Killer cell

CD5 dim, CD45, MHC1, MHC2, NKp46

CD5 (after 14 days in culture), CD4, CD21

  1. aPossibly unique to canines, CD4 is expressed in granulocytes. Similar to other species, CD4 is expressed in a subset of monocyte-derived cells
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