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Fig. 4 | Journal for ImmunoTherapy of Cancer

Fig. 4

From: Radiotherapy and MVA-MUC1-IL-2 vaccine act synergistically for inducing specific immunity to MUC-1 tumor antigen

Fig. 4

Leukocyte infiltration in Renca-MUC1 tumors treated with radiation and vaccine. Tumor sections obtained from the experiment described in Fig. 3 were also stained by IHC for CD45+ leukocytes, CD4+ TH cells, and CD8+ CTL and cells positive for these markers are shown (arrows). Control tumors showed minimal immune cell infiltration. Radiation showed focal infiltration of CD45+, CD4+, and CD8+ cells. Following radiation and vaccine, a massive infiltration of CD45+, CD4+, and CD8+ cells was observed in areas of tumor destruction. The extent of tumor destruction and immune infiltration was greater with Vaccine + Rad sequence than with Rad + vaccine sequence. All magnifications X40

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