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Table 1 Histological scoring of immune cell infiltrates in tumors treated with radiation and vaccine

From: Radiotherapy and MVA-MUC1-IL-2 vaccine act synergistically for inducing specific immunity to MUC-1 tumor antigen

  Control Radiation Rad + Vaccine Vaccine + Rad
F4/80+ cells + + +++ ++++
CD45+ cells + ++ ++++ ++++
CD4+TH cells ± ++ +++ ++++
CD8+ CTL cells + ++ ++++ ++++
  1. Tumors were either treated with the sequence of radiation followed by vaccine (Rad + Vaccine) or vaccine followed by radiation (Vaccine + Rad) as shown in Fig. 2a. The extent of inflammatory infiltration in treated tumors, which is presented in Figs. 3 and 4, was scaled from mild (±), moderate (+), strong (+ +), very strong (+ + +), to heavy (+ + + +) for immune cell markers including F4/80+ macrophages, CD45+ leukocytes, CD4+ TH cells and CD8+ CTL