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Table 3 Abscopal effect

From: Radiotherapy and MVA-MUC1-IL-2 vaccine act synergistically for inducing specific immunity to MUC-1 tumor antigen

  aResponders/Cured bImmune to Rechallenge cIFN-γ Mean Spots ± SD
  # Mice/Total Percent
Control 0/7 0% 0/7 N/A
Radiation 0/8 0% 0/8 N/A
Vaccine + Rad (Schedule 2) 4/8 50% 4/4 147.2 ± 7.8
  1. To test for abscopal effect, established Renca-MUC1tumors were treated either with vehicle (control), 8Gy radiation or vaccine followed by radiation (schedule 2, Fig. 2a). aResponders/Cured: Responders were characterized by inhibition of tumor growth or complete tumor regression. bAt an early time point after treatment, 7 days after radiation and one day after the second vaccine treatment, mice were rechallenged with Renca-MUC1 cells on the contralateral left flank. cOn day 70, the splenocytes of mice immune to rechallenge were tested in IFN-γ ELISPOT assay