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Table 3 Abscopal effect

From: Radiotherapy and MVA-MUC1-IL-2 vaccine act synergistically for inducing specific immunity to MUC-1 tumor antigen

 

aResponders/Cured

bImmune to Rechallenge

cIFN-γ Mean Spots ± SD

 

# Mice/Total

Percent

Control

0/7

0%

0/7

N/A

Radiation

0/8

0%

0/8

N/A

Vaccine + Rad (Schedule 2)

4/8

50%

4/4

147.2 ± 7.8

  1. To test for abscopal effect, established Renca-MUC1tumors were treated either with vehicle (control), 8Gy radiation or vaccine followed by radiation (schedule 2, Fig. 2a). aResponders/Cured: Responders were characterized by inhibition of tumor growth or complete tumor regression. bAt an early time point after treatment, 7 days after radiation and one day after the second vaccine treatment, mice were rechallenged with Renca-MUC1 cells on the contralateral left flank. cOn day 70, the splenocytes of mice immune to rechallenge were tested in IFN-γ ELISPOT assay
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