Table 1 Diagnostic tests in acute renal insufficiency after checkpoint inhibitors

 ANA titer

<40

<40

Negative

 CRP

97

37.9

0–3.0

 ESR

123

50

0–30

 ASO

47

32

<200

 Anti dsDNA by EIA

7

19

Negative

 ANCA SCR W/MPO/PR3 W/REFLEX

Negative

Negative

Negative

 ANA screen - serum

Negative

Positive

Negative

 Kappa Light Chains Free light chains

65.26

30.59

3.3–19.4

 Lambda light chain, free

29.59

19.03

5.7–26.3

 Kappa/ Lambda free

2.45

0.26–1.65

1.61

 Hepatitis profile – Acute panel

Negative

Negative

Negative

 HAV IgM, HCV Ab, ABB Core IGM, HBV Surface AG

 RPR

Non-reactive

Non-reactive

Non-reactive

 SM/RNP Antibodies

<0.1

<0.1

<0.1

 SM Antibodies

<0.1

<0.1

<0.1

 CPK

38

35

26–192

 C3

149

150

90–180

 C4

39.8

46.5

10.0–40.0

 Uric Acid

6.5

9.5

2.6–6

 Vitamin D 25

13.6

32.6

30–100

 PTH intact

105.6

79.2

11.1–79.5

 Calcium

8.9

8.9

8.5–10.1

 Protein total

7.8

6.8

6.4–8.2 g/dl

 Albumin

3.72

4.53

3.57–5.42 g/gl

 Alpha 1

0.66

0.46

0.19–0.4 g/dl

 Alpha 2

1.44

1.11

0.45–0.97 g/dl

 Beta 1

0.47

0.44

0.3–0.59 g/dl

 Beta 2

0.56

0.46

0.21–0.53 g/dl

 Gamma

0.94

0.79

0.71–1.54 g/dl

 Color

Straw

Yellow

Yellow

 Turbidity

Slightly cloudy

Clear

Clear

 Glucose

Negative

Negative

Negative

 Bilirubin

Negative

Negative

Negative

 Ketones

Negative

Negative

Negative

 pH

6.0

6.5

4.5–8

 Protein

Negative

Negative

Negative

 Specific gravity

1.005

1.01

Up to 1.035

 Blood

Small

Negative

Negative

 Urobilinogen

Negative

0.2

Negative

 Nitrites

Negative

Negative

Negative

 Leukocyte esterase

Large

Negative

Negative

 WBC, UA

38

Negative

Negative

 RBC, UA

3

Negative

Negative

 UBAC

+1

Negative

Negative

 Budding Yeast

Present

Negative

Negative

 White blood cell clump

Present

Negative

Negative