Table 2 Reported cases of immunotherapy associated AIHA
Case Report | Type of immunotherapy used | No of prior cycles | Type of malignancy | Mediator IgG or C3 | Treatment of AIHA | Immunotherapy Re-challenge | Other possible association for AIHA |
|---|---|---|---|---|---|---|---|
Schwab KS. et al. [9] | Nivolumab | 8 | Metastatic SCC of skin | IgG, C3 | Steroids | No | CLL |
Tardy MP. et al. [10] | Nivolumab | 2 | Hodgkin’s lymphoma | IgG | Steroids | Yes, 6 more injections. No recurrence of AIHA | None |
Kong BY. et al. [11] | Initially Ipilimumab then patient was started on Nivolumab | 4 | Metastatic melanoma | IgG | Steroids | No | Patient had positive direct anti-globulin test before starting Nivolumab. |
Palla AR. et al. [12] | Nivolumab | 2 | Metastatic lung cancer | C3 | Steroids | No | None |
Simeone E. et al. [13] | Ipilimumab | 3 | Metastatic melanoma | Unknown | Steroids | Unknown | None |
Simeone E. et al. [13] | Ipilimumab | 3 | Stage III melanoma | Unknown | Steroids | Unknown | None |
Simeone E. et al. [13] | Ipilimumab | 4 | Metastatic melanoma | Unknown | Steroids | Unknown | None |