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Table 2 Reported cases of immunotherapy associated AIHA

From: Immunotherapy-associated autoimmune hemolytic anemia

Case Report Type of immunotherapy used No of prior cycles Type of malignancy Mediator
IgG or C3
Treatment of AIHA Immunotherapy Re-challenge Other possible association for AIHA
Schwab KS. et al. [9] Nivolumab 8 Metastatic SCC of skin IgG, C3 Steroids No CLL
Tardy MP. et al. [10] Nivolumab 2 Hodgkin’s lymphoma IgG Steroids Yes, 6 more injections. No recurrence of AIHA None
Kong BY. et al. [11] Initially Ipilimumab then patient was started on Nivolumab 4 Metastatic melanoma IgG Steroids No Patient had positive direct anti-globulin test before starting Nivolumab.
Palla AR. et al. [12] Nivolumab 2 Metastatic lung cancer C3 Steroids No None
Simeone E. et al. [13] Ipilimumab 3 Metastatic melanoma Unknown Steroids Unknown None
Simeone E. et al. [13] Ipilimumab 3 Stage III melanoma Unknown Steroids Unknown None
Simeone E. et al. [13] Ipilimumab 4 Metastatic melanoma Unknown Steroids Unknown None