Fig. 1

Simulated example of process for evaluating candidate genes for marker-like co-expression in a tumor dataset. a Example of marker-like co-expression. Genes 1 and 2 are highly correlated with a slope of 1, a pattern consistent with both genes rising and falling at the same rate. b Example of two genes which cannot both be markers. Gene 3 exhibits no co-expression with gene 1, showing that Genes 1 and 3 are not both good markers for the same cell type. c Example of two genes which cannot both be markers. Gene 4 is highly correlated with Gene 1, but with a slope different than 1, meaning they are not both markers for the same cell type