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Fig. 4 | Journal for ImmunoTherapy of Cancer

Fig. 4

From: CCR7+ selected gene-modified T cells maintain a central memory phenotype and display enhanced persistence in peripheral blood in vivo

Fig. 4

Exhaustion and senescence following T cell selection. a PD1 expression of CD8+ and CD4+ T cells following selection prior to, or post 14 days expansion ex vivo. Statistical analysis was performed using two separate one-way ANOVAS. b CD8+ and c CD4+ T cell subpopulations of memory precursor effector cells (MPECs) KLRG1 CD127+, double positive effector cells (DPECs) KLRG1+ CD127+, short lived effector cells (SLECs) KLRG1+ CD127 or early effector cells (EECs) KLRG1CD127 following selection prior to, or post 14 days expansion ex vivo. Error bars show ± SEM

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