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Fig. 1 | Journal for ImmunoTherapy of Cancer

Fig. 1

From: Safety, tumor trafficking and immunogenicity of chimeric antigen receptor (CAR)-T cells specific for TAG-72 in colorectal cancer

Fig. 1

CC49-ζ vector diagram. A gamma retroviral CAR construct consisting of a TAG-72 antigen-binding domain derived from the humanized CC49 single-chain antibody linked to the CD3-ζ signaling domain of the T-cell receptor via a human CD4 transmembrane domain. CAR, chimeric antigen receptor; Fv, variable fragment; (G4-S)3, (Gly4, Ser)3 peptide linker; IC, intracellular; TM, transmembrane; VH, variable heavy chain; VL, variable light chain; γ1, immunoglobulin γ1

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