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Table 2 Anti-CC49-ζ immune responses in patients

From: Safety, tumor trafficking and immunogenicity of chimeric antigen receptor (CAR)-T cells specific for TAG-72 in colorectal cancer

Trial

Patient

TAG-72 post heat extraction (fold increase)

Anti-idiotype titer

1:100

1:1000

C-9701

101 F

8.1

++

++

 

201A

>2.6

+++

+++

 

202B

1.8

+++

+++

 

206 K

2.5

+

+

 

105 J

1.2

+

++

 

106 M

2.5

+

+

 

204D

UND

-

-

 

102G

>1.8

+++

++

 

205E

>1.0

++

++

C-9702

301B

1.3

+

++

 

303D

>1.4

+

++

 

401A

NA

+

-

  1. NA, data not available, UND TAG-72 undetectable.
  2. +, 1.5- to 3-fold increase; ++, 3.1- to 5-fold increase; +++, > 5-fold increase
  3. TAG-72 was detected in sera samples from IV-infused (trial C-9701) and intra-HA-infused (trial C-9702) CART72 cell patients following heat extraction of the TAG-72 to dissociate the antigen from inhibitory antibodies. Antibodies against the CC49 antibody were detected in all evaluable patients following infusion with CART72 cells comparing the RIA titer post-infusion versus pre-infusion. The detection of anti-CC49 antibodies coincided with the clearance of CART72 cells as measured by PCR