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Table 2 Anti-CC49-ζ immune responses in patients

From: Safety, tumor trafficking and immunogenicity of chimeric antigen receptor (CAR)-T cells specific for TAG-72 in colorectal cancer

Trial Patient TAG-72 post heat extraction (fold increase) Anti-idiotype titer
1:100 1:1000
C-9701 101 F 8.1 ++ ++
  201A >2.6 +++ +++
  202B 1.8 +++ +++
  206 K 2.5 + +
  105 J 1.2 + ++
  106 M 2.5 + +
  204D UND - -
  102G >1.8 +++ ++
  205E >1.0 ++ ++
C-9702 301B 1.3 + ++
  303D >1.4 + ++
  401A NA + -
  1. NA, data not available, UND TAG-72 undetectable.
  2. +, 1.5- to 3-fold increase; ++, 3.1- to 5-fold increase; +++, > 5-fold increase
  3. TAG-72 was detected in sera samples from IV-infused (trial C-9701) and intra-HA-infused (trial C-9702) CART72 cell patients following heat extraction of the TAG-72 to dissociate the antigen from inhibitory antibodies. Antibodies against the CC49 antibody were detected in all evaluable patients following infusion with CART72 cells comparing the RIA titer post-infusion versus pre-infusion. The detection of anti-CC49 antibodies coincided with the clearance of CART72 cells as measured by PCR