Skip to main content

Table 3 CART72 levels in tumor biopsies

From: Safety, tumor trafficking and immunogenicity of chimeric antigen receptor (CAR)-T cells specific for TAG-72 in colorectal cancer

Patient ID

CART72 delivery

Tumor biopsy location

Timing of biopsy

CC49-ζ by PCR (copies/106 cells)

Tumor

Blood

303D

HA

Liver

Day of 4th infusion

220

1937

301B

HA

Liver

2 weeks post 4th infusion

<50

<117

201A

IV

Rectum

Day of 5th infusion

<50

1704

  1. HA hepatic artery, IV intravenous, PCR polymerase chain reaction
  2. Levels of CC49-ζ modified CART72 cells were measured by PCR in tumor biopsies taken at variable time points post-CART72 infusion in three patients. CC49-ζ levels in biopsied tumor tissue were compared to levels in blood at corresponding time points. Patients 303D and 301B were treated in trial C-9702 and patient 201A was treated in trial C-9701