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Fig. 2 | Journal for ImmunoTherapy of Cancer

Fig. 2

From: Nuclear IRF-1 expression as a mechanism to assess “Capability” to express PD-L1 and response to PD-1 therapy in metastatic melanoma

Fig. 2

Characterization of IRF-1 in human melanoma samples. a Representative IRF-1-positive and IRF-1-negative melanoma cases from Yale tissue microarray (YTMA) 98. Green (Cy3 channel) = HMB45/S100 tumor mask. Red (Cy5 channel) = target. b Average AQUA scores for nuclear IRF-1 for 115 melanoma cases on YTMA 59. Blue bars = visible nuclear staining. Gray bars = no nuclear staining. c Overall survival in 115 melanoma cases unselected for treatment on YTMA 59 using visual threshold cutpoint. d Disease-specific survival for cases on YTMA 59 using visual cutpoint

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