Fig. 4
From: Vaccination with inhibin-α provides effective immunotherapy against testicular stromal cell tumors
Immunohistochemical analysis of autochthonous TSC tumors. a Testis tissue taken from normal 75 week-old male SJL/J mice showed normal non-transformed Leydig cells in the interstitial space between the seminiferous tubules (arrows; bar = 25 μm). b Testis tissue taken from 75 week-old male SJL.AMH-SV40Tag mice showed transformed Leydig cell tumors in the interstitial space between the seminiferous tubules (arrows; bar = 25 μm), and positive staining for (c) luteinizing hormone receptor (LHR), a traditional Leydig cell marker (arrows; bar = 10 μm), d anti- Müllerian hormone (AMH), a traditional Sertoli cell marker (arrows; bar = 10 μm), e the transgene derived SV40Tag in Leydig cells (short arrows) and Sertoli cells (long arrow; bar = 25 μm), and (f) inhibin-α, a protein commonly expressed in both Leydig cell tumors and Sertoli cell tumors (arrows; bar = 25 μm)