Fig. 5
From: Vaccination with inhibin-α provides effective immunotherapy against testicular stromal cell tumors
Vaccination against rmInα inhibits growth of autochthonous TSC tumors. Ten days after immunization of male SJL.AMH-SV40Tag (H-2s) transgenic mice with the immunodominant IAs-restricted Inα 215-234 peptide (a) LNC showed antigen-specific proliferation in response to various doses of Inα 215-234, and (b) whole LNC and purified CD4+ T cells but not CD8+ T cells showed high frequencies of antigen-specific IFNγ-secreting T cells in response to Inα 215-234. c Prophylactic Inα 215-234 vaccination of eight week-old male SJL.AMH-SV40Tag mice significantly inhibited the growth of autochthonous TSC tumors. d This inhibition of TSC tumor growth was accompanied by significantly lower testicular weights when the experiment was terminated at 77 weeks of age. Error bars indicate ± SE, and asterisks indicate significance