Fig. 4

Kaplan-Meier curves illustrating DFS and OS for all patients analyzed according to the density of CD8+ or CD163+ cells in the combined tumor regions (TC and IM) (a-d). e, f shows DFS and OS for all patients analyzed according to the combined density of CD8+ and CD163+ cells in the combined tumor regions (TC and IM). For explanation of favorable or unfavorable combined immune signatures (FCIS and UCIS, respectively) see “Results”. HH/HH: high densities for both CD8+ and CD163+ cells jointly analyzed in the combined tumor regions (CT/IM); Rest: LL/LL, HH/LL, and LL/HH. Statistically significant differences and hazard ratios between specific groups are given