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Table 3 Multivariate Cox proportional hazard analysis for DFS and OS of patients with non-metastatic invasive breast cancer

From: Differential intratumoral distributions of CD8 and CD163 immune cells as prognostic biomarkers in breast cancer

  DFS OS
Hazard Ratio P 95.0% CI for HR (range) Hazard Ratio P 95.0% CI for HR (range)
 TNM stageb 2.180 0.009 1.219–3.898 3.937 0.006 1.494–10.371
 Signaturesb 1.560 0.138 0.866–2.810 2.085 0.091 0.889–4.890
Model before stepwise selection
 Agea 1.031 0.948 0.411–2.589 4.391 0.188 0.486–39.703
 T statusb 2.613 0.010 1.255–5.439 3.679 0.028 1.148–11.793
 N stageb 1.222 0.512 0.671–2.225 1.125 0.815 0.420–3.010
 Gradeb 1.142 0.750 0.504–2.585 4.189 0.027 1.180–14.867
 HER-2/neu 0.928 0.884 0.342–2.520 0.066 0.016 0.007–0.606
 Hormone Receptors 0.277 0.004 0.277–0.669 0.168 0.007 0.046–0.621
 Signaturesb 2.063 0.041 1.031–4.126 4.850 0.014 1.374–17.122
Model after stepwise selection
 T statusb 2.999 0.001 1.602–5.615 3.522 0.005 1.477–8.398
 Hormone Receptors 0.269 0.002 0.116–0.621 0.231 0.014 0.072–0.742
 Signaturesb 2.146 0.027 1.091–4.219 4.273 0.006 1.521–11.999
  1. aAge under 50 and over 50 years old
  2. bAll categorical covariates were transformed into numeric codes as follows : T status (T1; 1, T2; 2, T3; 3), N stage (N0; 0, N1; 1, N2; 2, N3; 3), Grade (G1; 1, G2; 2, G3; 3), Signatures (FCIS; 1, Rest; 2, UCIS; 3) TNM stage (I; 1, II; 2, III; 3)