Skip to main content
Fig. 1 | Journal for ImmunoTherapy of Cancer

Fig. 1

From: Evaluation of dosing strategy for pembrolizumab for oncology indications

Fig. 1

Simulated distribution of steady-state AUC exposures (2800 replicate simulations) for the weight-based regimens of 2 mg/kg Q3W, 10 mg/kg Q3W, and 10 mg/kg Q2W compared with the simulated distribution of exposures for two potential fixed-dose regimens (log scale): Box: straight middle line = median; edges = 25th and 75th percentiles; whiskers = 10th and 90th percentiles; dots = 5th and 95th percentiles. Horizontal dashed lines represent the range of exposures (5th percentile of 2 mg/kg Q3W and 95th percentile of 10 mg/kg Q2W) from dose regimens demonstrated to have comparable efficacy and tolerability in melanoma and NSCLC trials

Back to article page